Hpmc k4m pdf
Different concentrations of HPMC-Lactose (filler) ratios were used to characterize the swelling and release behavior. In case of HPMC K15M and HPMC K100M the drug release prolonged for more than 24h.
Change in the density of granules, obtained after granulation with PEG 6000 and after addition of 5% and 10% HPMC K4M. It should also be noted that HPMC was used at two viscosity grades (k15M and k100M). The HPMC grade K4M (MWt 95000) was used to characterize the polymer chain disentanglement concentration (Cp) which influenced the polymer erosion. K4M, HPMC K15M and NaCMC, gas forming agent and passing the mixture through sieve no.20. Formula No.7 containing HPMC K4M (18.75% drugs) exhibited almost similar drug release profile in pH 7.5 phosphate buffer medium as that of marketed tablet. In this work, based on the related literature and our previous study, HPMC K4M and CMC-Na were chosen as to formulate the CGS system. The Korsmeyer peppas results showed that release follows anomalous or non-Fickian diffusion. The optimized batch was also analyzed for its morphological, physiochemical and drug release properties.
On the other hand, formulations (F4–F6) were prepared by replacing HPMC K4M with 40%, 45% and 50% of guar gum respectively. As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. The floating matrix tablets of Metoprolol tartrate were prepared by direct compression method.
The mechanism by which the drug release is slowed is the rapid formation of a hydrogel layer around the matrix following exposure to aqueous fluids, while the inner core of the polymeric matrix may remain dry or in a glassy state. The composition of HPMC K4M CR 40.00 mg and NaHCO3 35.39 mg produced the optimum formula of theophylline floating tablet with desirability value of 0.978. The viscosity specification range for HPMC K15M and HPMC K100M is 13275 – 24780 mPa.s and 75000 – 140000 mPa.s respectively.
As the amount of absorption of acyclovir from tablet, duodenal infusion and sipped the polymer in the formulations increase, the drug solution. HPMC K4M and CMC-Na are water absorbing or swelling polymers which are commonly used in the preparation of sustained release tablets. Interaction between a HPMC K4M- banana peel starch gives a significant effect to increase hardness. PolyoxTM coagulant (molecular weight 5 × 106 Da) and hydroxypropyl methylcellulose (HPMC) K4M (USP substitution type 2208) were used to identify the composition variables that ensure the production of polyethylene oxide (PEO) matrix tablets with the same dissolution characteristics as those containing HPMC. The investigators found that the studied formulation and the marketed formulation had similar release patterns and followed zero-order drug release by anomalous diffusion. Controlled release matrix tablets with HPMC K100LV, HPMC K4M, HPMC K15M, and HPMC K100M were formulated by wet (non-aqueous) granulation method using different proportion of polymers. Then, magnesium stearate after passing through 80-mesh screen is added and mixed for an additional 5 minutes.
posed of 80 mg of different ratios of HPMC K4M, Polycarbophyl (PAA1) and lactose and in formulations 12-16, Dicalcium phosphate (DCP) was used as filler. The ANOVA studies revealed that the formulations show significant effect in drug release. The highest percentage of HPMC dissolved was observed with K4M matrices and the lowest was observed with K100M matrices. Two grades of HPMC (K100 and K4M) in different proportions were used to prepare the tablets, and were evaluated for physical properties, drug content, in vitro drug release and drug release kinetics as well. The aim of the present work was to develop a gastroretentive floating tablet of Atenolol and investigate the effects of both hydrophilic and hydrophobic retardant on in vitro release. 61 HPMC types at different degrees of substitution (type E4M (DS = 1.9) and type K4M (DS = 62 1.4)) blended with rice flour-based batter increased the yield stress, apparent viscosity and k 63 (Amboon, Tulyathan, & Tattiyakul, 2012).
The incorporation of HPMC K4M into psyllium husk granule was observed to reduce the immediate swelling of the matrix and thus reduce its release . Floating lag time (FLT), total floating time (TFT) and time required to release 50 % of the drug (T 50 ) were selected as dependent variables.
2: Composition of tablets formulated with HPMCK15M.
HPMC is odorless, tasteless,non-toxic cellulose ethers produce from natural high molecular cellulose through series of chemical processing and chieved.It is white powder with good water solubility. The amount of HPMC K4M and stearic acid were found to significantly influence all in-vitro response parameters. Various grades of HPMC (K4M, 100M & 15M) were used as hydrophilic matrix polymer. Results from drug release study of pentoxifylline tab-lets obtained after granulation with 5 and 10% HPMC K4M, compared to the release profile of referent product.
HPMC-K4M at high concentrations increases weight and size uniformity, hardness, floating time, and swelling index. HPMC is safe, nonionic polymer that minimize interaction problems when they are used in acidic, basic, or other electrolytic system. Higher viscosity grades of HPMC ([email protected] K15M and KlOOM) were employed in six further 90 mg tablet formulations. The system was prepared by mixing drug, matrix-forming polymer (hydroxypropyl methylcellulose, HPMC) and fillers together.
Keywords: Psyllium, Theophylline, HPMC K4M, sustained release, dissolution, hydration, release mechanism and granulation. All the formulations were ev aluated for pH, clarity, drug content, gelling capacity, viscosity studies, invitro drug release studies, antimicrobial a ctivity. All other tableting excipient including carbopol 934P, sodium bicarbonate, magnesium stearate and lactose were of research grade and were sourced from BDH Laboratory (UK).
tumbling method using spatula for 14 minutes of HPMC K4M, PVP, and Lactose was added to the molten Zolpidem-PEG 6000 mixture and stirred well to mix. So, optimization was carried out by using central composite design by taking HPMC K4M and stearic acid as independent variables and floating lag time, % drug release for 3 h, % drug release for 8 h as dependent variables respectively. Tablets prepared by 30.0, 35.0 and 40.0% w/w HPMC K 100, 25.0% HPMC K 100 in combination with 5.0% HPMC K 4M and 15.0% w/w HPMC K 4M were conforming to USP limits, while tablets prepared by 15% K4M are not conforming to these limits. The maximum swelling for formulation F 1 (containing 40% of HPMC K4M) and formulation F 2 (containing 30% of HPMC K4M) was attained over 6 h and 5 h, respectively.
HPMC K4M CR was the dominant factor in lowering the Flag time, improving integrity of the tablet, and decreasing the release of drug. formulation F6 containing HPMC K4M & HPMC E15 in the ratio 1:1 showed good release pattern for 12 hours compared to other formulations. METHOCEL™ K4M Cellulose Ether Please Contact Dow for distribution options available for this product. Remaining quantity of HPMC K4M or HPMC K15M or HPMC K100M, Eudragit L-100 and colloidal silicon dioxide was mixed with the above prepared blend and final lubrication was done with magnesium stearate. HPMC K4M and PVPK30 was selected as the optimized batch since it showed the best drug release profile within 6 hours as compared to the other formulations. They had burst release of 32.80±0.8%, cumulative drug release at 12h (A 12) of 96.53±1.3%, T 50% of 03±0.12 h and floating lag time of 36±2s. HPMC K4M is a water swellable polymer which controls the release of drug from the core layer by forming a matrix or gel layer Indian J.Pharm. The formulation containing 25%w/w HPMC K4M as release retardant and Avicel PH 105 gave 96.59 ± 3.1% release at the end of 24h and fulfils regulatory requirement.
Compression-coated tablet of bisoprolol with 120mg HPMC K4M (B2) showed a lag time of 3.40±0.1 hrs with 99.81% drug release. The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2 3 factorial design. Whereas 110mg HPMC K100M (B5) showed a lag period 4.0±0.1 hrs with 98.91% drug release. The HPMC used in this study was K4M, K15M and K100M which their viscosity were 4000, 15000 and 100000 mPas respectively. A4M MC (Figure 6) Effectiveness of crystallization inhibition: E4M > A4M > K4M. A 100% drug release was achieved in formulation F7 when compared with formulation F6 which has a release of only 89 % in 24h.
All other ingredients used throughout the study were of analytical grades and were used as received. polymer to control the drug release, a combination of psyllium-HPMC and formulation processes should be considered in an attempt to achieve a zero-order release. Bookmark File PDF K4m Engine cheap shipping rates and local collection options, you can make an even bigger saving. VIVAPHARM ® HPMC, hypromellose, is a cellulose-based polymer for film coating, wet granulation, and hard capsule manufacturing.It is practically insoluble in hot water, acetone, anhydrous ethanol, and toluene and dissolves in cold water, resulting in a colloidal solution.
All the formulations showed compliance with the pharmacopoeial standards.
HPMC K4M in the concentration of 7% w/v showed 88.20 ± 0.056% cumulative drug release at the end of 10 h while the same concentration of acacia showed 85.22% ± 0.045%. Our results revealed a decrease in drug release rate from formulations (F1–F3) with increasing HPMC K4M concentration. The moisture sorption and desorption profiles of four different viscosity grades of (hydroxypropyl)methylcellulose (HPMC) 2208 (HPMC K100, HPMC K4M, HPMC K15M, and HPMC K100M) of different particle size fractions were analyzed according to the Young and Nelson equations. Sodium alginate in high concentrations was able to increase weight and size uniformity, floating time, swelling index, and mucoadhesive time. The optimization studies proved that the formulation containing drug, polymer (HPMC K4M) ratio of 1:1.5 (Formulation M3) is the most satisfactory formulation. HPMC K4M was received as a gift sample from Glenmark granules were evaluated in the dissolution medium 0.1 N Pharmaceuticals.
The cellulose acetate membrane was used for the determination of drug from the prepared transdermal matrix-type patches. Colorcon® is a world leader in the development, supply and support of formulated products for the pharmaceutical industry.