Electrokinetically driven microfluidics and nanofluidics pdf
Dissertation: Numerical Simulation for Microfluidic Devices and the Development of an Electrokinetically Controlled DNA Hybridization Chip. The generator has both, independent frequency and independent amplitude control for each channel. It is tempting to regard this as an extension of Moore's law, which predicts a constant rate of increase of the functionality of an electronic integrated circuit. Find helpful customer reviews and review ratings for Electrokinetically-Driven Microfluidics and Nanofluidics at Amazon.com. We proposed a microfluidic paper-based preconcentrator for scalable biomarker enrichment and reliable recovery using nanoelectrokinetic phenomenon.
Assoc Prof Wong's main research focus on two-phase flow and heat transfer, multiphase flows in microchannels, multi-fluid electroosmotic flow in microfluidic devices, liquid slug thermocapillary flows in microchannels, two-phase flow in evaporator, condenser and capillary tube expansion devices, heat driven pump and pulsating heat pipe for electronic cooling. Electroosmotic flow is amplified using different 2D and 3D model designs with alternate and geometric zeta potential values such as 25, 50, and 100 mV, respectively, to achieve high concentration mixing in the electrokinetically-driven microfluidic system. Among them, the electrokinetically driven flow is the most convenient mechanism for transporting fluid through microfluidic devices. Multiple passively adsorbed antigens captured antibodies present in samples, which then bound with TRITC-labeled detection antibodies to generate fluorescent signals. In-situ AC electroosmotic and thermal perturbation effects for wide range of ionic strength[J]. With this objective, interest is growing by year in electrokinetically driven microfluidics applied for the concentration, capture, filtration, transportation, and characterization of CTCs. Microfabricated devices for parallel and serial mixing of fluids are demonstrated. At the time, none of us had any experience in microfluidics or microfabriation but we persevered and solved many problems along the way.
The trend in electrokinetically driven microfluidic circuits is toward more complexity and functionality, which has mostly been achieved through the use of parallelism. A microfluidic thermal cycler for Polymerase Chain Reaction (PCR) has been modeled. 15 Unfortunately, it is difficult for biological prototypes to implement various essential physiological functions in vitro due to fragility and inactivation. Microfluidic devices for energy conversion: planar integration and performance of a passive, fully immersed H 2 –O 2 fuel cell. In this work, author has experimentally demonstrated the surface-driven capillary flow of dyed water in three individual microfluidic devices fabricated by polymeric materials.
My gratitude goes to my fellow colleagues, Jay Taylor and Razim Samy, who worked closely with me to setup the Lab during the first year of my study. Digital microfluidics is an alternative paradigm for lab-on-a-chip systems based upon micromanipulation of discrete droplets. The effect of surface wettability on surface-driven capillary flow is also investigated in PMMA microfluidic devices. In many biochemical protocols, such as polymerase chain reaction, a mixture of fluids in a certain ratio is repeatedly required, and hence a sufficient quantity of the mixture must be supplied for assay completion. Get Free Heat Transport In Micro To Nano Scale Solid State Devices Textbook and unlimited access to our library by created an account. Beginning with the modifications to the conventional equations as the scales go down to micron and sub-micron scales, the cases of flows driven using pressure and surface tension would be discussed.
Along with enabling integrated microfluidic system development, maker microfluidics addresses another key limitation in microfluidics: accessibility. This topic is of high relevance for electrokinetically-driven microfluidic and nanofluidic systems which are routinely used to process and analyze non-Newtonian fluids, such as biofluids, polymeric solutions and colloidal suspensions. The fabrication of the channels is particularly simple and uses standard milling and PDMS molding. The Microfluidics and Nanofluidics Handbook: Two-Volume Set comprehensively captures the cross-disciplinary breadth of the fields of micro- and nanofluidics, which encompass the biological sciences, chemistry, physics and engineering applications. Our device is a closed loop channel with an integrated acoustic micropump without external fluidic connections that allows for the investigation of small fluid samples in a continuous flow. The present invention comprises an electroosmotic flow pump with both anion and cation exchange beads packed in separate channels that pump towards an intersection. This paper discusses a scheme that uses the conductive solution in a microchannel made by PDMS, replacing electrodes and the way of dielectric breakdown to achieve microfluidic chip driver. Leslie is co-author of the book Electrokinetically Driven Microfluidics and Nanofluidics published by Cambridge University Press and currently serves as the Editor of the American Institute of Physics journal Biomicrofluidics as well as on the editorial boards of Interfacial Phenomena & Heat Transfer and Biosensors.
The electrokinetically driven, time-dependent reagent delivery processes were simulated using finite element method (FEM). Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles. A likely reason relates to the difficulty associated with handling high voltages in the high salt content buffer that is required for DNA hybridization. We present a computational investigation of the mechanism governing size-based particle separation in microfluidic pinched flow fractionation. Enhancement of Mixing in an Electrokinetically Driven Microfluidic T-Mixer Using Pulsating Electrical Field and Channel Geometry Effects. Flow control at microscale: Nanofluidics, microfluidics and millifluidics “Nanofluidics is the study of the behavior, manipulation, and control of fluids flow that are confined to structures of nanometer (typically 1-100 nm) characteristic dimensions (1 nm = 10-9 m). Among the unique properties of microfluidic devices is the ability to move liquids via electroosmosis.
We study the behavior of particles moving through a pinching gap (i.e., a constriction in the aperture of a channel) in the Stokes regime (negligible fluid and particle inertia) as a function of particle size. This work is authored as the study material for proposed elective-course on Microfluidics (M.Tech, Theory) in the Department of Mechanical Engineering, National Institute of Technology Arunachal Pradesh, India. The walls of the channel are assumed as sinusoidal wavy to analyze the peristaltic flow nature. Therefore, pressure driven flows for nanofluidics find niche applications.13,14 One notable aspect of nanofluidics, and perhaps micro-fluidics, is the ability for these systems to be a ‘unifier’ of physical principles. Thermo-driven nanofluidics are not artificial, and are ubiquitous in organisms where ion transport is regulated by ion channels in response to complex external stimuli, which lays the foundation for the life sciences. By means of numerical simulations, using a computational fluid dynamics software together with an optical ray tracing analysis platform, we show that we can tune various optical aberrations by electrically manipulating the shape of liquid lenses using one hundred individually addressable electrodes. This "Cited by" count includes citations to the following articles in Scholar. Combining the two flow streams results in higher flowrates for the pump and allows operation of the pump over a wide pH range.
New immobilized catalysts and catalytic processes.
There has recently been widespread interest in the use of AC electric fields, given the many advantages it offers over DC electrokinetics. Microfluidics refers to the behaviour, precise control, and manipulation of fluids that are geometrically constrained to a small scale (typically sub-millimeter) at which surface forces dominate volumetric forces. The microfluidic channel contains HSSs of different sizes and, subsequently, bubbles of different sizes that are independently driven by transducers bonded to the substrate adjacent to the channel.
Electrokinetically driven pumps, surface-chemistry-based pumps and the diffuse pump tech-nique will be discussed in detail. Chen CK, Cho CC (2008) Electrokinetically driven flow mixing utilizing chaotic electric fields. Together, Algar and I performed the QD surface modification and preparation of oligonucleotide-QD conjugates. Note that the velocity is assumed to be zero at the walls in most treatments of transport of liquids.
The suspended species are driven through an array of regularly spaced cylindrical posts by applying an electric field across the device. typicallyfocusingoneitherSAW-basedsensing4–8 orSAW-driven micro uidics.9–11 Our aim with this work is to overview devel-opments in both areas, and focus on some of the more recent trends that have arisen in the past several years that are driving SAW-based chemical analysis technology. Wheeler, Optimization of Device Geometry in Single-Plate Digital Microfluidics, Journal of Applied Physics, vol. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. Leslie is co-author of the book Electrokinetically Driven Microfluidics and Nanofluidics published by Cambridge University Press and currently serves as the Editor of the American Institute of Physics journal Biomicrofluidics as well as on the editorial boards of Scientific Reports and Interfacial Phenomena & Heat Transfer.
The separation of polystyrene microparticles in PMMA laboratory-on-a-chip systems is investigated with the reduction of separation time by air dielectric barrier discharge (DBD) plasma processing of channel surfaces. Read as many books as you like (Personal use) and Join Over 150.000 Happy Readers.
The pump can be used to deliver solutions ranging from a pH of about 2 to about 12. Design and Implementation of an Application Specific Multi-Channel Stimulator for Electrokinetically-Driven Microfluidic Devices . To simplify the voltage control hardware, electrokinetic mixing is effected using a single voltage source with the channels dimensioned to perform the desired voltage division. MICROFLUIDICS AND NANOFLUIDICS Overview The course would begin with a revision of the basic concepts of fluid mechanics and corroborate that to the understanding of microfluidics. Towards this end, we are developing a passive technique for concentrating particles in water-in-oil plugs which relies on the interaction between particle sedimentation and the recirculating vortices inherent to multiphase plug flow. Chakraborty “Flow and deformation characteristics of a flexible microfluidic channel with axial gradients in wall elasticity”, Soft Matter 16, 5777-5786 (2020). Microfluidics: Pressure Driven Flow 500nm Velocity profile in a microchannel with aspect ratio 2:5 under conditions of pressure driven flow Note that the velocity is assumed to be zero at the walls in most treatments of Self-assembly and Nanotechnology flow.